Yulia Artemenko

Research

Use of Dictyostelium discoideum to understand the molecular mechanisms of directed cell migration, a process that is important both in normal physiology, as well as in a host of pathophysiological conditions, including atherosclerosis and cancer metastasis. Focus on the signal transduction cascades involved in chemotaxis and shear flow-induced migration, the interplay between cell adhesion and directed cell migration, as well as the integration of various directional cues.

Specialty areas:

• Signal transduction
• Cell and molecular biology
• Live cell imaging

Publications

*Denotes undergraduate research student

• Cole A*, Buckler S*, Marcucci J* and Artemenko Y (2021) Differential Roles of Actin Crosslinking Proteins Filamin and α-Actinin in Shear Flow-Induced Migration of Dictyostelium discoideum. Front. Cell Dev. Biol. 9:743011. doi: 10.3389/fcell.2021.743011
• Artemenko, Y. and Devreotes, P.N. (2017) Assessment of Dictyostelium discoideum response to acute mechanical stimulation. JoVE. In press Artemenko, Y., Axiotakis, L. Jr, Borleis, J., Iglesias, P.A., Devreotes, P.N. Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks. Proc Natl Acad Sci U S A. 113(47):E7500-E7509
• Wang, M.J., Artemenko, Y., Cai, W.J., Iglesias, P.A., Devreotes, P.N. (2014) The directional response of chemotactic cells depends on a balance between cytoskeletal architecture and the external gradient. Cell Rep. 9(3):1110-21.
• Artemenko, Y., Batsios, P., Borleis, J., Gagnon, Z., Lee, J., Rohlfs, M., Sanséau, D., Willard, S.S., Schleicher, M., Devreotes, P.N. (2012) Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion. Proc Natl Acad Sci U S A. 109(34):13632-7.
• Artemenko, Y., Gagnon, A., Sorisky, A. (2009) Catalytically-inactive SHIP2 inhibits proliferation by attenuating PDGF signaling in 3T3-L1 preadipocytes. J Cell Physiol. 218(1):228-36.
• Artemenko, Y., Gagnon, A., Ibrahim, S., Sorisky, A. (2007) Regulation of PDGF-stimulated SHIP2 tyrosine phosphorylation and association with Shc in 3T3-L1 preadipocytes. J Cell Physiol. 211(3):598-607. 
• Artemenko, Y., Gagnon, A., Aubin, D., Sorisky, A. (2005) Anti-adipogenic effect of PDGF is reversed by PKC inhibition. J Cell Physiol. 204(2):646-53.
• Gagnon, A., Artemenko, Y., Crapper, T., Sorisky, A. (2003) Regulation of endogenous SH2 domain-containing inositol 5-phosphatase (SHIP2) in 3T3-L1 and human preadipocytes. J Cell Physiol. 197(2):243-50.

Education

• Ph.D., Biochemistry, University of Ottawa
• B.Sc., Biochemistry, University of Ottawa